The HeLa cell has many more chromosomes than a normal cell in weird unique positions in
HeLa Cell Karyotype various sizes.
Normal Cell Karyotype
HeLa cells may have this jumbled up overproduced mess of chromosomes because unlike normal cells they continue to reproduce at a rapid rate and are never really dormant. HeLa cells continue to grow and divide and grow and divide over and over and over again. Due to the fact this happens at such a fast exponential rate the cell is definitely prone to make more genetic mistakes in copying its DNA; this is most likely why HeLa cells chromosomes are so different. I also believe HeLa cells do not have a cell cycle control system to operate the molecules in the cell that both triggers and coordinates key events in the cell, because they don't need any trigger and they have no control, the frequency of cell division for a HeLa cell is constant. That would also explain why a HeLa cell has so many more chromosomes, whereas we only have two for each number HeLa cells can have up to 6 for each number, due to their rapid replication process.
cites
cites
1. http://www.htcl.cytspb.rssi.ru/tomors/HeLa-229.html
2. http://www.google.com/search?q=normal+cell+Karyotype&biw=1024&bih=441&source=lnms&tbm=isch&sa=X&ei=zIe2VMGiDfeIsQS88oGACQ&ved=0CAYQ_AUoAQ&safe=active&ssui=on#imgdii=_&imgrc=RsNcy8E_76I1lM%253A%3BcOuzGrhJSQkzsM%3Bhttp%253A%252F%252Fwww.amsbio.com%252Fimages%252Ffeatureareas%252FKSR%252520Karyotype.png%3Bhttp%253A%252F%252Fwww.amsbio.com%252Fserum-replacement.aspx%3B630%3B492
2. http://www.google.com/search?q=normal+cell+Karyotype&biw=1024&bih=441&source=lnms&tbm=isch&sa=X&ei=zIe2VMGiDfeIsQS88oGACQ&ved=0CAYQ_AUoAQ&safe=active&ssui=on#imgdii=_&imgrc=RsNcy8E_76I1lM%253A%3BcOuzGrhJSQkzsM%3Bhttp%253A%252F%252Fwww.amsbio.com%252Fimages%252Ffeatureareas%252FKSR%252520Karyotype.png%3Bhttp%253A%252F%252Fwww.amsbio.com%252Fserum-replacement.aspx%3B630%3B492
I liked the pictures you chose, they were very clear and interesting to look at. I liked your explanation of why HeLa cells reproduce at a very rapid rate. Your explanation was clear and concise. I learned that HeLa cells can have up to 6 chromosomes. Overall a very good blog.
ReplyDeleteYour explanation of the differences between a cancer and normal cell karyotype were very clear and understandable. I agree that cancer cells do not have a control system, although you may want to mention the specifics of the control system in a normal cell. Such as, contact inhibition, anchorage dependence, and PCD.
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